Antioxidant therapy in the complex treatment of patients with ischemic stroke in the acute and recovery period

Improvement of therapy patients with ischemic stroke (IS) remains a relevant problem, despite the widespread use drug and mechanical revascularization methods during recent years. One pathogenetic mechanisms IS is oxidative stress as one components brain tissue damage in acute period factor that prevents processes repair neuroplasticity recovery period. This rationale for antioxidant drugs periods stroke. Data from clinical studies on antioxidants treatment are presented. We describe domestic dimephosphone (dimethyloxobutylphosphonyl dimethylate), synthetic non-anticholinesterase organophosphorus compound, which has wide range effects: antioxidant, antacidotic, vasodilating, membrane stabilizing, anti-inflammatory, etc. given no indications thrombolytic therapy, there was decrease neurological deficit disability. The positive results chronic cerebrovascular insufficiency described. data our own study complex cognitive rehabilitation A statistically significant functions registered according to Montreal Cognitive Scale (MoCA), an increase MoCA score by 2 points or more 59.6% patients. An improvement executive functions, flexibility control processes, predominance verbal thinking over sensory-perceptual were noted.